Thyroid Nodule Impedance Measurement System (TN_IMS)

Description

Innovative Thyroid Nodule Diagnostic Device

The Thyroid Nodule Impedance Measurement System (TN-IMS) is an innovative thyroid nodule diagnostic device that delivers real-time, high-accuracy diagnosis during thyroid cancer procedures. Designed for intraoperative and minimally invasive use, TN-IMS is changing the way clinicians assess and manage thyroid nodules.

Why TN-IMS Is a Game Changer in Thyroid Cancer Care

Thyroid cancer has seen a significant rise globally, particularly in the detection of small, clinically silent papillary carcinomas. While this progress is largely due to imaging advancements, traditional diagnostic tools like fine-needle aspiration (FNA) and frozen-section pathology still fall short in clarity and consistency.

That’s where TN-IMS steps in.

Using electrical impedance spectroscopy (EIS), TN-IMS measures two impedance features — Z1kHz and Impedance Phase Slope (IPS) — to differentiate between high-risk nodules requiring excision and low-risk nodules that can be safely monitored.

How It Works: Precision Through Impedance

A sterile G20 I.V. needle is inserted into the nodule under ultrasound guidance, while a skin-surface electrode connects to the system. Within seconds, TN-IMS provides a real-time evaluation based on biophysical tissue properties. Its technology eliminates the guesswork from intraoperative decisions.

This real-time thyroid nodule evaluation technology saves time, reduces unnecessary surgical interventions, and enhances confidence for both surgeon and patient.

Clinical Study Performance

In clinical evaluation, TN-IMS showed outstanding diagnostic performance:

Sensitivity: 94%
Specificity: 87%
Accuracy: 91%

Among 90 thyroid nodule cases, the device detected 48 nodules via radiology, identified 3 during surgery, and missed only 3 cases — showing excellent performance in both detection and exclusion.

These results affirm TN-IMS as a high-accuracy thyroid nodule detection system validated by histopathology.

Applications and Benefits

Real-time intraoperative assessment
Reduces unnecessary thyroid lobectomy or total thyroidectomy
Increases diagnostic clarity for BI-RADS III–VI nodules
Minimally invasive and surgeon-friendly
Enhances early diagnosis and patient outcomes
Ideal for patients with dense breast tissue or a family history of thyroid cancer

Backed by Research, Patents, and Clinical Innovation

Developed by Hospitech Cancer Care Innovations, TN-IMS is part of a growing suite of oncology tools, including:

Cancer Diagnostic Probe (CDP)
Impedimetric Tumor Detection System (ITDS)
Electrical Endoscopy Mass Detection (EMD)
ElectroChemoTherapy (ECT) & Gamma Probe

Each product, including TN-IMS, is supported by clinical studies, peer-reviewed publications, and multiple U.S. patents, making Hospitech a leader in oncology diagnostic innovation.

Partner with Hospitech

Distributors, investors, and surgical oncology centers worldwide are invited to explore the global distribution of thyroid diagnostic equipment powered by TN-IMS. This next-generation device is ready for scaling across markets where fast, precise, and minimally invasive cancer diagnostics are in demand.

Upgrade Your Surgical Suite with TN-IMS

Equip your clinical team with the TN-IMS device for thyroid cancer diagnosis and set a new standard in thyroid care. Join the shift toward smarter, safer, and more personalized cancer treatment.

TECHNOLOGY

Technology of Thyroid Nodule Impedance Measurement System

The Thyroid Nodule Impedance Measurement System (TN-IMS) is an advanced device that utilizes precision impedance-based measurement technology to analyze thyroid nodules. Using a two-electrode probe, the device stimulates the tissue and records a current response signal, which is then processed to calculate impedance magnitude and phase diagrams. The extracted parameters, impedance magnitude at 1 kHz (Z1kHz) and impedance phase slope in the frequency range of 100 kHz to 500 kHz (IPS), offer valuable insights into intracellular, extracellular, and membranous abnormalities associated with cancer development.

The TN-IMS is designed for ease of use, with measurements taking only about 3 seconds to complete. The results are displayed in real-time, providing immediate feedback to clinicians. During the process, a disposable G20 IV cannula is inserted into the suspicious target nodule, while a disposable ECG chest electrode with a pre-gelled Ag/AgCl sensor is attached to the submental skin of the patient.

The device’s calibration is based on histopathological examinations, ensuring accurate and reliable results. With its advanced technology and user-friendly design, the TN-IMS device is an invaluable tool for healthcare professionals in diagnosing and managing thyroid nodules.

FEATURES

Hospitech Thyroid Nodule Impedance Measurement System Features

Real-time detection: detects high-risk thyroid nodules intra-operatively before starting any dissection
High sensitivity and specificity: 92% and 85%, respectively, tested on 103 samples
No need for presurgical radiologic reports
Can score newly found nodules or multinodular lesions without prior information
Facilitates decision-making when considering a lobectomy or total thyroidectomy, especially in the absence of frozen section pathology
Accurate results: detects high-risk nodules by analyzing Z1kHz and IPS signals
Potential to reduce unnecessary surgical procedures and improve patient outcomes

ACHIEVEMENT

Articles

National Library of Medicine

Surgery Today

CLINIAL TRIAL RESULTS

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1. What is the Thyroid Nodule Impedance Measurement System (TN-IMS)?

TN-IMS is a novel device that utilizes electrical impedance spectroscopy to provide real-time, high-accuracy detection of high-risk thyroid nodules, improving patient outcomes and reducing unnecessary surgeries.

2. How does the TN-IMS work?

The device measures two electrical impedance features of thyroid nodules, Z1kHz and IPS, to distinguish between malignant nodules that require excision and low-risk nodules that only need follow-up.

3. What are the key benefits of using TN-IMS?

TN-IMS offers real-time detection of high-risk nodules, high sensitivity (94%) and specificity (87%), eliminates the need for pre-surgical radiologic reports, and aids in surgical decision-making, particularly in the absence of frozen section pathology.

4. How accurate is the TN-IMS in detecting thyroid nodules?

The system has shown an overall accuracy of 91% in diagnosing samples, effectively identifying a majority of both high-risk and low-risk nodules during evaluations.

5. Can TN-IMS be used intra-operatively?

Yes, TN-IMS can detect high-risk thyroid nodules during surgery before any dissection begins, allowing for immediate clinical decision-making.

6. What conditions does the TN-IMS help differentiate?

The device can effectively distinguish between malignancy and benign conditions such as normal thyroid tissue and colloid goiter.

7. How does TN-IMS improve patient outcomes?

By accurately identifying high-risk nodules, TN-IMS helps reduce the number of unnecessary surgeries, ensuring that only patients who truly need intervention undergo surgical procedures.

8. What was the method of validation for TN-IMS?

The performance of TN-IMS was validated through a cohort study involving histopathological comparisons, confirming its effectiveness in accurately diagnosing thyroid nodules based on impedance measurements.