Checking the cavity-side margins during surgery for breast cancer patients is critical to ensure the definitive removal of suspicious and high-risk lesions with minimal damage to normal tissue. Remaining cancer cells in the breast causes re-surgeries and inevitable post-surgical treatments, which will have several side effects. Frozen pathology of tumor margins during surgery is a clinically accepted procedure to guide the surgeon to any need for re-excision. However, the time-consuming and expert dependent process of margin examination and false diagnostics, especially in neoadjuvant cases, are limitations of this procedure. CDP (Cancer Diagnosis Probe) system, has been introduced as a surgical assistant system in breast cancer surgery.
The new system reveals the cancerous cells in the internal margins (cavity-side margin) within a few millimeters in 40 seconds, using a needle sensor. This system has a clinical diagnostic classification matching with the pathological results of the tested tissues. The CDP response peaks are based on the classification of the pathological system (Ductal intraepithelial neoplasia (DIN), Lobular intraepithelial neoplasia (LIN), and Fibro epithelial lesion (FEL) (according to the latest reported revisions)).
The distinctive ability of CDP to detect cancer cells in the internal margins (after tumor dissection) has the sensitivity and selectivity of 97% and 94%, respectively.
CDP in the Lymph Node Mode
Involved lymph node detection is also performed based on measuring the impedimetric properties associated with Fatty Acid Oxidation (FAO), which is the most dominant cancer cell metabolism in the lymph node environment.
Statistical Diagnostic Results of CDP in the margin and Lymph nodes
* Percentage reduction of the involved margins remaining in the patient’s body with the help of CDP despite performing Frozen-section and Permanent Pathology on tumor side margins (%)